SidaGhanaV1, Main, Exploration, bibRecord, 000928

Highly Active Antiretroviral Therapy and Employment Status in Accra, Ghana

Identifieur interne : 000928 ( Main/Exploration ); précédent : 000927; suivant : 000929

Highly Active Antiretroviral Therapy and Employment Status in Accra, Ghana

Auteurs : Iw Howley [États-Unis] ; M. Lartey ; J T Machan [États-Unis] ; E A Talbot [États-Unis] ; A. Obo-Akwa ; T P Flanigan [États-Unis] ; A. Kwara [États-Unis]

Source :

Ghana Medical Journal [ 0016-9560 ] ; 2010.

RBID : PMC:3052831

Abstract

SummaryObjectives

This study investigated the immunologic responses and employment history of highly-active antiretroviral therapy (HAART) patients.

Design

We interviewed patients and reviewed medical records to collect demographic, clinical, and employment history while on HAART. Demographic characteristics were tested as predictors of immunological response while on HAART using hierarchical linear models.

Setting

Fevers Unit, Korle-Bu Teaching Hospital, Accra, Ghana

Participants

Subjects comprised a convenience sample of adult HAART patients receiving therapy for at least 9 months. 270 patients were interviewed. 38 were excluded due to inadequate time on HAART or inability to locate all necessary patient information.

Intervention

This was an observational study. Main outcome measures: We investigated the change in CD4 cell count and weight since the initiation of therapy, and their ability to maintain or regain employment as well as the reasons for this.

Results

The estimated mean ± standard error increase in CD4 cell count from baseline at 6, 12, and 18 months were 102 ± 5, 204 ± 11, and 236 ± 10 cells/µL, respectively. Overall, 147 patients (63.4%) reported remaining employed or obtaining new employment while on HAART. Patients who were asymptomatic at initial presentation were more likely to remain employed or returned to work while on HAART than those who were symptomatic (66.4% vs. 48.8%, P = 0.009). Most patients were employed in the informal sector, which made their economic situation particularly vulnerable to HIV-associated illness.

Conclusion

The findings suggest that patients receiving HAART experience good clinical and immunological responses as well as improvement in employment status.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052831

PubMed: 21416048
PubMed Central: 3052831

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Objectives</title>
<p>This study investigated the immunologic responses and employment history of highly-active antiretroviral therapy (HAART) patients.</p>
</sec>
<sec><title>Design</title>
<p>We interviewed patients and reviewed medical records to collect demographic, clinical, and employment history while on HAART. Demographic characteristics were tested as predictors of immunological response while on HAART using hierarchical linear models.</p>
</sec>
<sec><title>Setting</title>
<p>Fevers Unit, Korle-Bu Teaching Hospital, Accra, Ghana</p>
</sec>
<sec><title>Participants</title>
<p>Subjects comprised a convenience sample of adult HAART patients receiving therapy for at least 9 months. 270 patients were interviewed. 38 were excluded due to inadequate time on HAART or inability to locate all necessary patient information.</p>
</sec>
<sec><title>Intervention</title>
<p>This was an observational study. Main outcome measures: We investigated the change in CD4 cell count and weight since the initiation of therapy, and their ability to maintain or regain employment as well as the reasons for this.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The estimated mean ± standard error increase in CD4 cell count from baseline at 6, 12, and 18 months were 102 ± 5, 204 ± 11, and 236 ± 10 cells/µL, respectively. Overall, 147 patients (63.4%) reported remaining employed or obtaining new employment while on HAART. Patients who were asymptomatic at initial presentation were more likely to remain employed or returned to work while on HAART than those who were symptomatic (66.4% vs. 48.8%, P = 0.009). Most patients were employed in the informal sector, which made their economic situation particularly vulnerable to HIV-associated illness.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>The findings suggest that patients receiving HAART experience good clinical and immunological responses as well as improvement in employment status.</p>
</sec>
</div>
</front>
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Le SIDA au Ghana (serveur d'exploration)

Highly Active Antiretroviral Therapy and Employment Status in Accra, Ghana

Highly Active Antiretroviral Therapy and Employment Status in Accra, Ghana

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